This book moves toward building a new and more comprehensive theory of literature, philosophy, psychology, and art. The extremely popular work of Ken Wilber, unites the best of both western and eastern thought and affirms that the stages of consciousness, more refined than that of the reasoning mind, do exist.

The heme‐containing cytochromes P‐450 are a ubiquitous family of monooxygenase isozymes responsible for the oxidative metabolism of a wide variety of endogenous as well as exogenous compounds. Many of the compounds metabolized by this enzyme system are effectively detoxified and converted to derivatives more easily eliminated from the organism. However, some compounds can be activated to reactive species capable of eliciting a cascade of toxic lesions, including cancer. Since its discovery nearly 30 years ago, the cytochrome P‐450 enzyme system has (...) received a great deal of attention, particularly in the areas of their mechanisms of metabolism, range of substrate specificity, the purification and characterization of the multiple isozymes and, more recently, the regulation of expression of specific forms. This review will discuss current notions concerning the expression of at least one cytochrome P‐450 isozyme and future directions that should lead to a more complete understanding of cytochrome P‐450 gene expression in general, particularly as it impacts upon biochemical pharmacology. (shrink)

Investigations into the relationship between attention and awareness appear to agree on one thing; the former is neither necessary nor sufficient for the latter. I argue that this might be a mistake. I look at a series of blindsight experiments, which conclude that attention occurs in the absence of awareness. By combining these cases with a widely accepted neurophysiological model of attention, I claim that the experiments are not nearly as compelling as they initially appear. I conclude by showing that (...) this position potentially generalizes to cover other purported, non- pathological cases of dissociation between attention and awareness. This leaves rational space for the possibility that attention is both necessary and sufficient for consciousness, and thus of a ‘free explanatory trade-up' from a theory of the first to a theory of the second. This would constitute a significant step in solving the ‘easy' problem of consciousness. (shrink)

Löwe and von Hartel have drawn attention to the striking similarity between R's contents and those of a lost manuscript bequeathed by Philippe d' Harcourt to the library at Bee. This manuscript is described in a twelfth-century catalogue as follows:7 ‘in alio Seneca de naturalibus questionibus et Adelermus Batensis [Adhelardus Bathonensis Becker), Proba vates, Aurea Capra, et liber Hildeberti Turonensis archiepiscopi de dissensione interioris et exterioris hominis, et sermones eius et uita ipsius.’.

Löwe and von Hartel have drawn attention to the striking similarity between R's contents and those of a lost manuscript bequeathed by Philippe d' Harcourt to the library at Bee. This manuscript is described in a twelfth-century catalogue as follows:7 ‘in alio Seneca de naturalibus questionibus et Adelermus Batensis [Adhelardus Bathonensis Becker), Proba vates, Aurea Capra, et liber Hildeberti Turonensis archiepiscopi de dissensione interioris et exterioris hominis, et sermones eius et uita ipsius.’.

What is xenophobia? Why is xenophobia immoral? How is xenophobia's conceptual and moral meaning diminished? Investigations of these questions would invigorate xenophobia as a topic in public morality and discourage the public's acquiescing to xenophobia's new prominence. This paper focuses on the third question, the diminishment of xenophobia. In the first section, I outline a general conception of xenophobia. In the second, I explain how theories of membership in liberal democratic societies relegate xenophobia to a minor moral concern. And, in (...) the third, that the conflation of xenophobia with racism disadvantages the former. How liberal Democratic nations imagine membership and how those nations imagine racism shelters xenophobia. (shrink)

Among psychologists and vision scientists,binocular rivalry has enjoyed sustainedinterest for decades dating back to the 19thcentury. In recent years, however, rivalry''saudience has expanded to includeneuroscientists who envision rivalry as a tool for exploring the neural concomitants ofconscious visual awareness and perceptualorganization. For rivalry''s potential to berealized, workers using this tool need toknow details of this fascinating phenomenon,and providing those details is the purpose ofthis article. After placing rivalry in ahistorical context, I summarize major findingsconcerning the spatial characteristics and thetemporal dynamics (...) of rivalry, discuss two majortheoretical accounts of rivalry ( eye vs stimulus rivalry) and speculate on possibleneural concomitants of binocular rivalry. (shrink)

BLWith new text and full apparatus criticus The Eudemian Ethics was one of two ethical treatises which Aristotle wrote on the subject of ethica or `matters to do with character'. Although the two works cover much the same ground, the Nicomachean Ethics is better known; the poor manuscript tradition of the Eudemian Ethics has made correct translation and interpretation of the text extremely difficult. The subject of the work is the choice of a certain means of conduct, made by a (...) `man of practical wisdom', between two extremes of behaviour: asceticism and yielding to uncontrolled impulses. Aristotle also stresses the notion of moral intention and the importance of virtue of character. This new Oxford Classical Text of the Eudemian Ethics is the result of many years of work. After Sir David Ross's death, his original text was substantially reworked and revised by his friend and colleague R. R. Walzer, who was aided in the revision by his former pupil Mrs Jean Mingay, who continued his work after his death in 1974. Mrs Mingay was fortunate in being able to make use of previously unpublished contributions from D. J. Allan after his death in the late seventies, and more recently has been helped in her work by the suggestions of Professor D. A. Russell, David Robinson, and Christopher Rowe. (shrink)

The high precision attained by cosmological data in the last few years has increased the interest in exact solutions. Analytic expressions for solutions in the Standard Model are presented here for all combinations of Λ = 0, Λ ≠ 0, κ = 0, and κ ≠ 0, in the presence and absence of radiation and nonrelativistic matter. The most complete case (here called the ΛγCDM Model) has Λ ≠ 0, κ ≠ 0, and supposes the presence of radiation and dust. (...) It exhibits clearly the recent onset of acceleration. The treatment includes particular models of interest such as the ΛCDM Model (which includes the cosmological constant plus cold dark matter as source constituents). (shrink)

Sexual reproduction is a composite, not a singular, phenomenon and as such can be subdivided into a number of componentsi.e. fusion, recombination, fission, and the male-female phenomenon. These components can evolve independently, though any evolutionary change in one component is likely to influence the future evolution of the other components. The ambiguity that surrounds the term ‘sex’ due to a failure to recognise the composite nature of sexual reproduction has led to considerable confusion in past discussions of the evolution of (...) the phenomenon. This paper considers the possible chronological interaction of the components of sexual reproduction both with each other and with the sequence of selective pressures that seem likely to have acted. This chronological approach is used to consider: the origin of sexual reproduction; the evolution of sexual reproduction in the common ancestor of the procaryotes and eucaryotes; the modification of the ancestral system in the procaryote line following the procaryote-eucaryote dichotomy; and the modification of the ancestral system in the eucaryote line up to the origin of the male-female phenomenon.It is suggested that the fusion and recombination of the first living organisms were chronological continuations of the fusion and recombination of complex organic molecules that led up to the origin of life. The evolution of the third major component of sexual reproductioni.e. fission , by definition coincided with the origin of life. Initial selection on the components of sexual reproduction are likely to have been related to the optimum manifestations of size, complexity, diversity, multiplication, and distribution. Resultant early evolutionary trends are likely to have been: selective fusion between more-similar organisms; increase in number of fissions per fusion; and less recombination.The procaryote-eucaryote dichotomy is argued to have evolved in response to the increasing cellular problems of packing and replicating an increasing amount of hereditary material. The evolution of a single circular hereditary organelle in the procaryote line is argued to have led to the loss of total fusion and the specialisation of individuals into either donors or recipients. The donor-recipient phenomenon of procaryotes is directly analogous to the male-female phenomenon of eucaryotes and leads to parallel evolution due to sexual selection in both groups. In the eucaryote line the ancestral mechanism of sexual reproduction is argued to have persisted through, but to have been greatly modified by, the evolution of complex machinery for the handling of multiple hereditary organelles at cell division and reduction division. The evolutionary modification of the ancestral system of sexual reproduction is suggested to have led in eucaryotes to the evolution of: the species phenomenon; allelic recombination; and the male-female phenomenon. (shrink)

The third international conference on classical influences took place in Cambridge in 1977 under the title 'Classical Influences in Western Education, Philosophy and Social Theory'. Dr Bolgar has here collected and edited the proceedings and produced a volume which attempts to relate the progress of classical studies to the general history of ideas from the mid-seventeenth to the mid-nineteenth century. The book should be of interest to specialists in classical studies, to students of the literature of the period, and to (...) students of eighteenth-century French, Italian and American history. (shrink)

Almost all ethical guidelines and legislative policies concerning biomedical research involving human subjects contain provisions about relevance of research for the participating populations, informed consent, adequate care for research induced injuries and several other safeguards but the poor continue to suffer. Globalization has further aggravated poor people’s vulnerability by exposing them to international markets. Since the developing countries are abode of higher population of the poor they have become the unholy mines of this human ore for researchers. In this paper (...) I examine various dimensions of poverty and analyze the international ethical responses in the area of biomedical research involving human subjects in order to determine their adequacy to protect the poor against exploitation and misuse and conclude that in view of the poor’s inherent and extreme vulnerability and the failure of ethical pronouncements to protect them from misuse and exploitation, they should be excluded from being enrolled as research subjects. (shrink)

This invaluable resource is the first one-volume, in-depth, comprehensive history of modern science ever published.

Today, the tone of discussion in the public sphere is dominated by misunderstanding. A common assumption is that misunderstanding comes from a failure of understanding. This article argues that misunderstanding is in fact a type of meaning change. To fully understand the contrast between misunderstanding as a failure of understanding and misunderstanding as a type of meaning change, the article uses Ludwig Wittgenstein and Hans-Georg Gadamer as a starting point to tease out an unthought assumption. Both thinkers challenge traditional preconceptions (...) of how language shapes understanding and they make prominent use of the concept of misunderstanding to do so. Yet both rely on a de facto model of misunderstanding as a failure of understanding. To consider an alternative notion of misunderstanding, the article looks at examples from thinkers influenced by Wittgenstein's and Gadamer's philosophy. Finally, the article concludes by positing a new definition of misunderstanding. (shrink)

Розкрито сутність поняття «рейтинг». Доведено значущість рейтингової оцінки для суб’єктів фінансового ринку, зокрема для страхових компаній, потенційних страхувальників, інвесторів та кредиторів.

Despite stringent and fine tuned laws most jurisdictions are not able to curb organ trafficking. Nor are they able to provide organs to the needy. There are reports of the kidnapping and murder of children and adults to “harvest” their organs. Millions of people are suffering, not because the organs are not available but because “morality” does not allow them to have access to the organs. Arguments against organ sale are grounded in two broad considerations: sale is contrary to human (...) dignity, and sale violates equity. Both these objections are examined in this article and it is concluded that they reflect a state of moral paternalism rather than pragmatism. It is argued that a live human body constitutes a vital source of supply of organs and tissues and that the possibilities of its optimum utilisation should be explored. Commercialisation should be curbed not by depriving a needy person of his genuine requirements but by making the enforcement agencies efficient. (shrink)